Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

Neji, Sourour; Hadrich, Ines; Trabelsi, Houaida; Abbes, Salma; Cheikhrouhou, Fatma; Sellami, Hayet; Makni, Fattouma; Ayadi, Ali

doi:10.1186/s12929-017-0376-2

Journal of Biomedical Science

Table 6 Antifungal susceptibility to the azoles and relative quantification of gene expression and gene copy number of ERG11, CDR1, MDR1 and MRR1 genes in Candida parapsilosis

From: Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

Strain	Posaconazole		Fluconazole		Itraconazole		Ketoconazole		Voriconazole		RNA relative quantification				DNA relative quantification
	MIC	I	MIC	I	MIC	I	MIC	I	MIC	I	ERG11	CDR1	MDR1	MRR1	ERG11	CDR1	MDR1	MRR1
TN157HC02	0,016	ND	0,5	S	0,064	S	0,008	ND	0,008	S	1153	0,527	1259	1169	1367	2042	1087	3437
TN180HC04	0,032	ND	0,25	S	0,125	S	0,008	ND	0,008	S	0,445	2296	0,379	0,696	0,317	12,977	0,203	0,227
TN330HC04	0,032	ND	0,5	S	0,016	S	0,008	ND	0,008	S	0,595	0,693	0,901	0,733	6578	9570	6364	7141
TN176HC05	0,064	ND	1	S	0,064	S	0,016	ND	0,016	S	0,489	0,309	0,781	0,589	0,296	0,217	0,019	0,034
TN419HC05	0,016	ND	0,5	S	0,008	S	0,008	ND	0,008	S	0,314	1045	0,053	0,117	0,357	0,461	0,105	0,958
TN597HC06	0,032	ND	1	S	0,064	S	0,016	ND	0,016	S	0,367	1890	0,074	0,081	0,773	1613	0,247	3938
TN81HC07	0,032	ND	0,25	S	0,032	S	0,008	ND	0,008	S	0,579	1457	0,524	2108	1961	1597	3665	0,895
TN123HC07	0,032	ND	0,5	S	0,032	S	0,016	ND	0,032	S	1123	1729	0,327	0,731	0,973	0,766	1061	1971
TN826HC08	0,016	ND	1	S	0,064	S	0,008	ND	0,016	S	1525	0,538	0,584	0,909	1421	1220	1257	0,979
TN28HC09	0,08	ND	1	S	0,064	S	0,008	ND	0,016	S	1046	1196	2352	1166	0,929	1005	0,866	0,562
TN144HC09	0,125	ND	2	S	0,032	S	0,016	ND	0,016	S	0,948	0,378	0,312	0,364	0,502	1006	0,343	2949
TN14HC11	0,032	ND	0,25	S	0,064	S	0,008	ND	0,008	S	1644	0,077	0,000	0,052	0,261	1877	0,495	1913
TN70HC02	0,5	ND	4	SDD	0,5	SDD	0,064	ND	0,125	S	2115	1841	2192	2812	4434	7221	3060	13,487
TN377HC03	0,5	ND	4	SDD	0,25	SDD	0,125	ND	0,125	S	3518	12,990	13,401	25,498	0,506	2129	0,327	2977
TN19HC08	0,5	ND	4	SDD	0,25	SDD	0,064	ND	0,5	SDD	0,906	0,819	0,375	0,761	0,469	0,881	0,636	1659
TN659HC08	0,032	ND	4	SDD	0,5	SDD	0,125	ND	0,32	SDD	1055	1363	1381	0,725	1486	2482	0,878	0,907
TN87HC09	0,125	ND	4	SDD	0,032	S	0,016	ND	0,016	S	0,697	1365	0,472	0,558	0,503	0,617	0,303	2681
TN452HC15	0,032	ND	0,5	S	0,25	SDD	0,125	ND	0,125	S	1899	3504	1213	2489	0,411	1066	0,649	2711
TN33HC06	1	ND	16	R	0,5	SDD	0,25	ND	0,25	SDD	0,518	0,880	0,971	0,874	1792	7426	1342	10,307
TN460HC13	0,016	ND	0,5	S	0,016	S	16	ND	8	R	0,238	2184	1845	1313	0,568	1319	0,392	3028
TN80HC15	0,5	ND	32	R	0,25	SDD	0,032	ND	0,008	S	2277	11,320	1563	2886	3320	0,490	2572	1425
TN87HC15	0,5	ND	32	R	0,25	SDD	0,032	ND	0,008	S	2013	11,097	2016	2845	3472	0,444	2604	1262

I interpretation, ND Not determined due to lack of validated clinical breakpoints, S susceptible, SDD dose-dependent susceptible, R resistant, MIC in μg/ml

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ISSN: 1423-0127

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