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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Conditioned place preference training prevents hippocampal depotentiation in an orexin-dependent manner

Fig. 2

Home cage pairings with saline or cocaine injections in mice failed to prevent LFS-induced hippocampal depotentiation in vitro. a: The schema for a 3-day home cage parings with saline and cocaine (20 mg/kg, i.p.) injections under the same protocol as used in the CPP training stage. Hippocampal slices were prepared on Day 4. b: Time courses of the slope of fEPSPs recorded before, during TBS and LFS, and after LFS in hippocampal slices prepared from untreated naïve mice and mice receiving saline or cocaine injections at their home cage. Inset: Averaged traces of 20 fEPSPs recorded before (a) and 60 min after (b) LFS in each group. c: Bar graphs summarize the magnitudes of potentiation of fEPSP slope in the three groups of mice in b. Depotentiation was induced, analyzed and presented as described in Fig. 1

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