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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Oxidative toxicity in diabetes and Alzheimer’s disease: mechanisms behind ROS/ RNS generation

Fig. 2

Oxidative stress production and damage in T2DM. Hyperglycemia is considered as major contributor in ROS production and associated- damage in T2DM. Induced glucose concentrations may have led to glucose autoxidation, impaired mitochondrial bioenergetics and over production of ROS. Induced oxidative stress in T2DM can impair a couple of transcription factors and pathways like P13K, JAK/STAT, JNK, p-38, ERK/MAPK and CDC42 that resulted in insulin resistance. The other glycolytic intermediates can have led to microvascular complications and endothelial dysfunctions and prone to several diabetic complications

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