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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Rosmarinic acid induces rabbit articular chondrocyte differentiation by decreases matrix metalloproteinase-13 and inflammation by upregulating cyclooxygenase-2 expression

Fig. 2

Ros. A regulates the inflammatory response in rabbit articular chondrocytes. Rabbit primary cultured articular chondrocytes were treated with or without the indicated concentrations of rosmarinic acid (Ros. A) for 24 h or 75 μg/mL Ros. A for the specified time periods. a and b Expression levels of COX-2 were determined by western blotting (upper panel). Actin was used as a loading control. The relative amounts of COX-2 were quantified by densitometry measurements (Image J) (lower panel). c and d Prostaglandin E2 (PGE2) production was measured using a PGE2 assay kit. The results represent three independent experiments. Values shown are the means ± SD: *p < 0.05 vs. control cells

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