From: Psoriasis-associated vascular disease: the role of HDL
HDL functions | |
Cholesterol reverse transport | Cholesterol taken up from peripheral tissues, esterified and transferred to HDL for transport to the liver |
Cholesterol efflux |
Cholesterol and phospholipids removal from macrophages Interaction with cellular receptors: ABCA1, ABCG1, SR-BI |
Anti-inflammatory activity |
Inhibition of VCAM-1 expression in endothelial cells Removal of oxidized pro-inflammatory lipids from cells and lipoproteins |
Antioxidative |
Inhibition of LDL oxidation Removal of oxidized lipids from cells and ox-LDL Scavenging of ROS |
Cytoprotective |
Inhibition of endothelial cell apoptosis Efflux of toxic oxysterols |
Vasodilatory |
Induction of NO production Inhibition of superoxide release |
Anti-thrombotic |
Inhibition of platelet aggregation Activation of eNOS |
Anti-infectious | Interaction with LPS |