From: Psoriasis-associated vascular disease: the role of HDL
HDL functions | |
 Cholesterol reverse transport | Cholesterol taken up from peripheral tissues, esterified and transferred to HDL for transport to the liver |
 Cholesterol efflux | Cholesterol and phospholipids removal from macrophages Interaction with cellular receptors: ABCA1, ABCG1, SR-BI |
 Anti-inflammatory activity | Inhibition of VCAM-1 expression in endothelial cells Removal of oxidized pro-inflammatory lipids from cells and lipoproteins |
 Antioxidative | Inhibition of LDL oxidation Removal of oxidized lipids from cells and ox-LDL Scavenging of ROS |
 Cytoprotective | Inhibition of endothelial cell apoptosis Efflux of toxic oxysterols |
 Vasodilatory | Induction of NO production Inhibition of superoxide release |
 Anti-thrombotic | Inhibition of platelet aggregation Activation of eNOS |
 Anti-infectious | Interaction with LPS |