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Table 1 Main atheroprotective HDL functions

From: Psoriasis-associated vascular disease: the role of HDL

HDL functions
 Cholesterol reverse transport Cholesterol taken up from peripheral tissues, esterified and transferred to HDL for transport to the liver
 Cholesterol efflux Cholesterol and phospholipids removal from macrophages
Interaction with cellular receptors: ABCA1, ABCG1, SR-BI
 Anti-inflammatory activity Inhibition of VCAM-1 expression in endothelial cells
Removal of oxidized pro-inflammatory lipids from cells and lipoproteins
 Antioxidative Inhibition of LDL oxidation
Removal of oxidized lipids from cells and ox-LDL
Scavenging of ROS
 Cytoprotective Inhibition of endothelial cell apoptosis
Efflux of toxic oxysterols
 Vasodilatory Induction of NO production
Inhibition of superoxide release
 Anti-thrombotic Inhibition of platelet aggregation
Activation of eNOS
 Anti-infectious Interaction with LPS
  1. HDL high-density lipoproteins, ABCA1 ATP-binding cassette transporter A1, ABCG1 ATP-binding cassette transporter G1, SR-BI scavenger receptor class B type I, VCAM-1 vascular cell adhesion molecule-1, LDL low-density lipoprotein, ox-LDL oxidized LDL, ROS reactive oxygen species, NO nitric oxide, eNOS endothelial nitric oxide synthase