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Table 3 Serum LH and testosterone efficacy parameters according to “on versus off LH-RH agonist” in the validation cohort

From: Accuracy of serum luteinizing hormone and serum testosterone measurements to assess the efficacy of medical castration in prostate cancer patients

Marker Sensitivity Specificity Efficiency PPVa NPVb
Serum LHc 124/126 (98.4) 17/17 (100) 141/142(98.6) 124/124 (100) 17/17 (89.5)
Serum testosterone (CLIA)d 106/126 (84.1) 6/17 (35.3) 112/143 (78.3) 106/117 (90.6) 6/26 (23.1)
Serum testosterone (LC MSMS)e 123/126 (97.6) 5/17 (29.4) 128/143 (89.5) 123/135 (91.1) 5/8 (62.5)
  1. a PPV positive predictive value, b NPV negative predictive value, c LH Luteinizing hormone, d CLIA Chemiluminiscent immunoassay, e LC MSMS Liquid chromatography tandem mass espectrometry