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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Fig. 3

a Mortality in ASD mice. Fifty-one percent early postnatal mortality in ASD-affected DTg (12 out of 23 by 3 weeks of age), compared to 100% 3-week survival in the non-DTg and non-ASD DTg groups. b Gender difference in mortality. Male ASD mice (n = 14) had higher mortality than female ASD mice (n = 9, 79% vs 11%; P = 0.003). c Early mortality is associated with poor weight gain. There is no difference in average bodyweights among ASD DTg mice and other groups at birth. However, the average body weight at 14 days after birth is significantly lower in the ASD DTg mice. ASD DTg non-survivor (NS) group n = 4; ASD DTg - survivor (S) group, n = 6; non-ASD DTg, n = 9; non-DTg group, n = 40. **P < 0.01, *P < 0.05

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