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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Fig. 4

Regulation of the MEK-ERK signaling pathway in 14.5 dpc hearts from two different aMEK1 transgenic models. Despite evidence of aMEK1 expression in the atria of both TAMEK/MH DTg and MEK1 single Tg mice, increased ERK1/2 phosphorylation was documented only in the DTg. *P < 0.05. P-ERK1/2 = Phospho-ERK1/2; A1/V1 = pooled atrial and ventricular tissues, respectively, from TAMEK/MH DTg; A2/V2 = pooled atrial and ventricular tissues, respectively, from TAMEK/MH WT sibling controls; A3/V3 = pooled atrial and ventricular tissues, respectively, from MEK1 single Tg; A4/V4 = pooled atrial and ventricular tissues, respectively, from MEK1 WT sibling controls. Original blots available in Additional file 7 S7

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Journal of Biomedical Science

ISSN: 1423-0127