Table 1 Echocardiographic measurements of LV function in 8-week old mice bearing different transgenic genotypes
Genotype (TAMEK/MH) | −/− | +/− | −/+ | +/+ |
|---|---|---|---|---|
BW(g) | 22 ± 1 | 21 ± 0 | 21 ± 0 | 22 ± 0 |
EF(%) | 75 ± 0 | 75 ± 0 | 76 ± 0 | 64 ± 2* |
FS(%) | 48 ± 0 | 48 ± 0 | 48 ± 0 | 37 ± 2* |
IVSd (mm) | 0.51 ± 0.05 | 0.53 ± 0.06 | 0.51 ± 0.05 | 0.48 ± 0.05 |
IVSs (mm) | 0.65 ± 0.11 | 0.66 ± 0.11 | 0.65 ± 0.10 | 0.60 ± 0.09 |
LVAWd (mm) | 0.80 ± 0.06 | 0.83 ± 0.06 | 0.79 ± 0.05 | 0.78 ± 0.06 |
LVAWs (mm) | 1.15 ± 0.09 | 1.15 ± 0.08 | 1.11 ± 0.08 | 1.10 ± 0.08 |
LVIDd (mm) | 3.70 ± 0.08 | 3.74 ± 0.09 | 3.67 ± 0.07 | 4.11 ± 0.09* |
LVIDs (mm) | 2.51 ± 0.13 | 2.55 ± 0.10 | 2.48 ± 0.09 | 2.51 ± 0.10* |
n | 5 | 5 | 5 | 5 |