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Table 1 Echocardiographic measurements of LV function in 8-week old mice bearing different transgenic genotypes

From: Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

Genotype
(TAMEK/MH)
−/− +/− −/+ +/+
BW(g) 22 ± 1 21 ± 0 21 ± 0 22 ± 0
EF(%) 75 ± 0 75 ± 0 76 ± 0 64 ± 2*
FS(%) 48 ± 0 48 ± 0 48 ± 0 37 ± 2*
IVSd (mm) 0.51 ± 0.05 0.53 ± 0.06 0.51 ± 0.05 0.48 ± 0.05
IVSs (mm) 0.65 ± 0.11 0.66 ± 0.11 0.65 ± 0.10 0.60 ± 0.09
LVAWd (mm) 0.80 ± 0.06 0.83 ± 0.06 0.79 ± 0.05 0.78 ± 0.06
LVAWs (mm) 1.15 ± 0.09 1.15 ± 0.08 1.11 ± 0.08 1.10 ± 0.08
LVIDd (mm) 3.70 ± 0.08 3.74 ± 0.09 3.67 ± 0.07 4.11 ± 0.09*
LVIDs (mm) 2.51 ± 0.13 2.55 ± 0.10 2.48 ± 0.09 2.51 ± 0.10*
n 5 5 5 5
  1. BW body weight, EF ejection fraction, FS fractional shortening, IVS interventricular septum, LVAW left ventricular anterior wall, LVID left ventricular internal dimension; +/+ group includes ASD mice only; please see Additional file 6 S6 for data from +/+ non-ASD mice. *P < 0.05