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Table 2 Similarities between human ASD and the MEK1-mediated mouse ASD model

From: Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

  Human ASD MEK1 ASD mouse model
Gender distribution at birth 51% male 56% male
Gender dependent long term survival ate 65% survivors were female (>5 years) 89% survivors were female (21 days)
Major mortality stage Early, first year after birth (75% of total death) Early, before weaning (100% of death till 8wk old)
Growth impairment Weight and length Weight and length