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Table 2 Similarities between human ASD and the MEK1-mediated mouse ASD model

From: Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

 

Human ASD

MEK1 ASD mouse model

Gender distribution at birth

51% male

56% male

Gender dependent long term survival ate

65% survivors were female (>5 years)

89% survivors were female (21 days)

Major mortality stage

Early, first year after birth (75% of total death)

Early, before weaning (100% of death till 8wk old)

Growth impairment

Weight and length

Weight and length