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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease

Fig. 3

Potential role of ZIP7-mediated glucose metabolism in skeletal muscle. The ZIP7-gated release of zinc from the Golgi apparatus and/or the endoplasmic reticulum activates the phosphorylation of AKT and the subsequent mobilization of the glucose transporter GLUT4 which in turn brings glucose into the cytosol. Zinc also inactivates the negative regulation of insulin signalling, PTP-1B which allows the insulin signalling cascade process. The role of zinc activation of insulin receptor substrates (IRS) is not known (dashed lines)

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