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Table 2 ZIKV NS5 predicted epitopes 100% conserved among ZIKV lineages and DENV serotypes and their respective population coverage rates (%) considering the Brazilian population

From: In silico design of a Zika virus non-structural protein 5 aiming vaccine protection against zika and dengue in different human populations

Epitope Locationa Alleles Population coverage
LSRNSTHEMY 211–220 HLA-A*01:01 13.87%
CVYNMMGKR 451–459 HLA-A*03:01, HLA-A*31:01, HLA-A*33:03 12.06%
CVYNMMGKREK 451–461 HLA-A*03:01, HLA-A*11:01 12.06%
AIWYMWLGAR 474–483 HLA-A*31:01 11.06%
WYMWLGAR 476–483 HLA-A*31:01, HLA-A*33:03, HLA-C*04:01 33.73%
RAIWYMWLGAR 473–483 HLA-A*33:03 3.9%
IWYMWLGAR 475–483 HLA-A*31:01, HLA-A*33:03 11.06%
LEFEALGF 485–492 HLA-B*18:01, HLA-C*04:01 8.0%
YADDTAGW 532–539 HLA-C*03:03, HLA-C*05:01, HLA-C*08:02, HLA-C*17:01 9.64%
RAIWYMWL 473–480 HLA-C*03:03, HLA-C*07:02, HLA-C*15:02 9.64%
YADDTAGWDT 532–541 HLA-C*05:01, HLA-C*08:02 9.7%
YADDTAGWDTR 532–542 HLA-C*05:01, HLA-C*08:02 9.7%
YADDTAGWD 532–540 HLA-C*05:01, HLA-C*12:03 9.7%
ADDTAGWD 533–540 HLA-C*05:01 9.7%
GRGGWSYY 83–90 HLA-C*07:01, HLA-C*07:02 23.83%
SRNSTHEM 212–219 HLA-C*07:01, HLA-C*07:02 23.83%
SRNSTHEMY 212–220 HLA-C*07:01, HLA-C*07:02 23.83%
SRNSTHEMYW 212–221 HLA-C*07:01 23.83%
SRAIWYMWL 472–480 HLA-C*07:02 19.15%
  1. aLocation of the predicted epitope into the ZIKV NS5 consensus amino acid sequence