Table 2 ZIKV NS5 predicted epitopes 100% conserved among ZIKV lineages and DENV serotypes and their respective population coverage rates (%) considering the Brazilian population
Epitope | Locationa | Alleles | Population coverage |
|---|---|---|---|
LSRNSTHEMY | 211–220 | HLA-A*01:01 | 13.87% |
CVYNMMGKR | 451–459 | HLA-A*03:01, HLA-A*31:01, HLA-A*33:03 | 12.06% |
CVYNMMGKREK | 451–461 | HLA-A*03:01, HLA-A*11:01 | 12.06% |
AIWYMWLGAR | 474–483 | HLA-A*31:01 | 11.06% |
WYMWLGAR | 476–483 | HLA-A*31:01, HLA-A*33:03, HLA-C*04:01 | 33.73% |
RAIWYMWLGAR | 473–483 | HLA-A*33:03 | 3.9% |
IWYMWLGAR | 475–483 | HLA-A*31:01, HLA-A*33:03 | 11.06% |
LEFEALGF | 485–492 | HLA-B*18:01, HLA-C*04:01 | 8.0% |
YADDTAGW | 532–539 | HLA-C*03:03, HLA-C*05:01, HLA-C*08:02, HLA-C*17:01 | 9.64% |
RAIWYMWL | 473–480 | HLA-C*03:03, HLA-C*07:02, HLA-C*15:02 | 9.64% |
YADDTAGWDT | 532–541 | HLA-C*05:01, HLA-C*08:02 | 9.7% |
YADDTAGWDTR | 532–542 | HLA-C*05:01, HLA-C*08:02 | 9.7% |
YADDTAGWD | 532–540 | HLA-C*05:01, HLA-C*12:03 | 9.7% |
ADDTAGWD | 533–540 | HLA-C*05:01 | 9.7% |
GRGGWSYY | 83–90 | HLA-C*07:01, HLA-C*07:02 | 23.83% |
SRNSTHEM | 212–219 | HLA-C*07:01, HLA-C*07:02 | 23.83% |
SRNSTHEMY | 212–220 | HLA-C*07:01, HLA-C*07:02 | 23.83% |
SRNSTHEMYW | 212–221 | HLA-C*07:01 | 23.83% |
SRAIWYMWL | 472–480 | HLA-C*07:02 | 19.15% |