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Table 2 Twelve-Lead ECG, SAECG, and EPS Findings in Patients With or Without the G Allele of rs1805124 (H558R+ Group or H558R- Group)

From: H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters

  H558R- Group (N = 91) H558R+ Group (N = 9) P value
ECG
 Spontaneous type1 Brugada ECG in V1 lead 74.7% 33.3% 0.01
 Spontaneous type1 Brugada ECG in V2 lead 40.2% 33.3% 0.68
 ST in V1 (mV) 2.8 ± 1.4 1.7 ± 0.5 0.0003
 ST in V2 (mV) 4.2 ± 1.8 2.4 ± 1.3 0.0038
 J points in V1 (mV) 3.3 ± 2.2 2.3 ± 0.5 0.19
 J points in V2 (mV) 4.8 ± 2.4 3.5 ± 1.6 0.12
 PQ (ms) 170 ± 33 174 ± 23 0.76
 QRS (ms) 120 ± 44 106 ± 16 0.61
 QT (ms) 397 ± 33 407 ± 24 0.36
 QTc (ms) 413 ± 34 425 ± 23 0.32
SAECG
 Filtered QRS duration (ms) 163 ± 29 155 ± 26 0.48
 RMS 40 (μV) 13 ± 10 11 ± 6 0.67
 LAS 40 (ms) 50 ± 15 53 ± 14 0.62
 Positive late potentials (%) 76.3% 66.6% 0.53
EPS
 AH (ms) 100 ± 20 90 ± 18 0.23
 HV (ms) 49 ± 12 48 ± 11 0.77
 AVN refractory period (ms) 385 ± 114 306 ± 151 0.12
 Sinus node recovery time (ms) 1319 ± 450 1273 ± 87 0.80
  1. ECG electrocardiogram, SAECG signal-averaged ECG, EPS electrophysiological study, RMS 40 root mean square voltage (40 ms), LAS 40 low-amplitude signal