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Table 2 Twelve-Lead ECG, SAECG, and EPS Findings in Patients With or Without the G Allele of rs1805124 (H558R+ Group or H558R- Group)

From: H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters

 

H558R- Group (N = 91)

H558R+ Group (N = 9)

P value

ECG

 Spontaneous type1 Brugada ECG in V1 lead

74.7%

33.3%

0.01

 Spontaneous type1 Brugada ECG in V2 lead

40.2%

33.3%

0.68

 ST in V1 (mV)

2.8 ± 1.4

1.7 ± 0.5

0.0003

 ST in V2 (mV)

4.2 ± 1.8

2.4 ± 1.3

0.0038

 J points in V1 (mV)

3.3 ± 2.2

2.3 ± 0.5

0.19

 J points in V2 (mV)

4.8 ± 2.4

3.5 ± 1.6

0.12

 PQ (ms)

170 ± 33

174 ± 23

0.76

 QRS (ms)

120 ± 44

106 ± 16

0.61

 QT (ms)

397 ± 33

407 ± 24

0.36

 QTc (ms)

413 ± 34

425 ± 23

0.32

SAECG

 Filtered QRS duration (ms)

163 ± 29

155 ± 26

0.48

 RMS 40 (μV)

13 ± 10

11 ± 6

0.67

 LAS 40 (ms)

50 ± 15

53 ± 14

0.62

 Positive late potentials (%)

76.3%

66.6%

0.53

EPS

 AH (ms)

100 ± 20

90 ± 18

0.23

 HV (ms)

49 ± 12

48 ± 11

0.77

 AVN refractory period (ms)

385 ± 114

306 ± 151

0.12

 Sinus node recovery time (ms)

1319 ± 450

1273 ± 87

0.80

  1. ECG electrocardiogram, SAECG signal-averaged ECG, EPS electrophysiological study, RMS 40 root mean square voltage (40 ms), LAS 40 low-amplitude signal
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Journal of Biomedical Science

ISSN: 1423-0127