Fig. 8

Schematic representation of the signaling pathways. OSS induces a sustained increase in the association of TβRII and TβRI with integrin β1 and β3 in ECs plated on FN, but only induces a transient association in ECs plated on LM. These differential effects of FN and LM on EC responses to OSS may contribute to the differential regulations of these ECM proteins in Smad2 and NF-κB activations and downstream pro-inflammatory gene expression in ECs in response to OSS