Fig. 1
From: Impact of social relationships on Alzheimer’s memory impairment: mechanistic studies
Schematic diagram illustrates how social isolation exacerbates memory decline in APP/PS1 mice. We propose that social isolation increases calpain activity leading to conversion of p35 to p25. Decrease in membrane associated p35 reduces α-CaMKII synaptic distribution resulting in the synaptic removal of AMPARs