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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activity

Fig. 3

Pyr-1 significantly suppresses growth of MDA-MB-231 breast cancer cells in cell culture and nude mouse models. Clockwise: a Cells were treated with Pyr-1 or cisplatin control at indicated dose, and IC50 was determined after 48 h by viability staining. b Nude mice were implanted with tumor cells, and therapy with Pyr-1 (blue) or DMSO solvent control (red) was initiated 6 days later. Average tumor size reduction in Pyr-1-treated versus control group is shown in percentiles. **, p < 0.001 (by one-way ANOVA). c Mouse body weight was recorded to monitor potential treatment-associated toxicity. d 16 days after treatment, study was terminated, tumors were excised and average weight was determined. *, p < 0.05 compared to DMSO control (by Student’s t test analysis)

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