Fig. 5From: Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activityPyr-1 (4 h treatment) induced autophagy in A375 cells as shown by acridine orange staining which could be completely blocked by bafilomycin A1 (BafA), PD98059 (PD), or PD + LY294002 (LY), but only partially blocked by LY. No autophagy was seen in control-treated cellsBack to article page