|
Tissue
|
Pyr-1, IC50 (nM)
|
CB533, IC50 (nM)
|
Control, IC50 (nM)
|
|---|
|
Breast
|
|
BT4740
|
2.1
|
5.7
|
Dox: > 105
|
|
MCF-7
|
2.8
|
72.8
|
Cis: 14,800
|
|
SK-BR-3
|
1
|
5.4
|
Cis: 99,410
|
|
Colon
|
|
CoLo205
|
3.2
|
42.9
|
Mit: 2610
|
|
DLD-1
|
10.1
|
227
|
Cis: 4680
|
|
HCT116
|
1.6
|
163.5
|
Mit: 4290
|
|
HT29
|
4.7
|
170.3
|
Cis: 10,570
|
|
SW480
|
1.4
|
88.4
|
Cis: ≈105
|
|
SW620
|
0.9
|
55.3
|
Cis: > 105
|
|
Prostate
|
|
LNCaP
|
18
|
1540
|
Cis: 13,520
|
|
DU145
|
19
|
405.8
|
Cis: 1680
|
|
PC-3
|
5.9
|
76.8
|
Cis: 18,270
|
|
Pancreas
|
|
BxPC-3
|
4.5
|
108.8
|
Cis: 5550
|
|
PANC-1
|
1.2
|
267
|
Cis: 4300
|
|
MIA PaCa-2
|
16.9
|
283.9
|
Cis: 13,540
|
|
Lung
|
|
A549
|
9.9
|
36.9
|
Cis: 11,740
|
|
CaLu-6
|
14.4
|
242.3
|
Cis: 2380
|
|
NCI-H460
|
6.9
|
714.6
|
Cis: 780
|
|
NCI-H1703
|
19.5
|
nt
|
Cis: 13,670
|
|
SK-MES-1
|
12.8
|
382.5
|
Cis: 14,480
|
|
Myeloma
|
|
RPMI-8226
|
12.6
|
59
|
Cis: 11,010
|
|
Ovary
|
|
SK-OV-3
|
60.1
|
666.6
|
Mit: 1060
|
|
OVCAR-3
|
0.6
|
46.8
|
Cis: 6310
|
|
Liver
|
|
Hep 3B
|
76.2
|
197
|
Cis: 6950
|
|
Hep G2
|
3.5
|
46.5
|
Mit: 2700
|
|
SK-HEP-1
|
48
|
1454
|
Mit: 3500
|
|
Stomach
|
|
BGC-823
|
10.5
|
172.5
|
Cis: 1250
|
|
MCG803
|
3.3
|
179.3
|
Cis: 6550
|
|
NCI-N87
|
2.2
|
310.3
|
Cis: 5830
|
|
Head and Neck
|
|
KB
|
11.2
|
120.4
|
Cis: 12,340
|
|
CNE2
|
8.4
|
971.6
|
Cis: 11,820
|
|
Kidney
|
|
786-O
|
39.5
|
986.4
|
Cis: 4280
|
|
Sarcoma
|
|
HT-1080
|
12.9
|
663.3
|
Dox: 320
|
|
143B
|
19.1
|
1360
|
Mit: 1480
|
|
Melanoma
|
|
A375
|
14.3
|
334.5
|
Cis: 7100
|
|
SK-MEL-5
|
13.3
|
245.5
|
Cis: 5130
|
|
A2058
|
1.7
|
511.5
|
Cis: 7240
|
|
Glioma
|
|
U-87 MG
|
40
|
2144
|
Cis: 4480
|
|
Leukemia
|
|
K-562
|
7.4
|
99.6
|
Cis: 2700
|
- Dox doxorubicin, Mit mitomycin C, Cis Cisplatin
