Fig. 6

a Line graph shows the time course of percentage changes in MAP (left) and HR (right) after ICV injection of different doses of NOC-18, an 00000NO donor (n = 3 each). The average BP and HR 60 min before NOC-18 injection are taken as baseline (b) of 100%. *p < 0.05 compared with baseline using repeated measure one way ANOVA followed by Dunnett’s posttests. b Line graph show time course of percentage change in MAP (left) and HR (right) after administration of ethanol with or without ICV treatment with 12 nmol NOC-18 (n = 4) on day 8 treatment of ethanol. NOC-18 was given immediately after ethanol administration. The average BP and HR 60 min before ethanol administration are taken as baseline (b) of 100%. #P < 0.05 compared with no ICV treatment using repeated measure two-way ANOVA followed by Bonferroni post-test