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Table 6 Unique non-synonymous single nucleotide polymorphisms (SNPs) associated with penicillin binding proteins (PBPs) and other virulent genes found in all ten pneumococcal isolates isolates

From: Comparative genomic analysis of ten clinical Streptococcus pneumoniae collected from a Malaysian hospital reveal 31 new unique drug-resistant SNPs using whole genome sequencing

Locus Name Putative Identification Reference
TIGR4 SNP Pneumococcal isolate Amino Acid Change
SP_0346 cpsA; capsular polysaccharide biosynthesis protein 320,234 C T SPS7, SPS8, SPS10 A53V
320,204 C T SPS7, SPS8 A43V
320,872 C T SPS10 P266S
321,451 G A SPS10 V459 M
320,657 C T SPS9, SPS10 S194 L
321,460 A G SPS2 I462V
321,485 T C SPS7, SPS8 V470A
320,710 A G SPS1 T212A
322,321 A G SPS10 K20E
322,360 G A SPS2 G33S
323,191 A C SPS1, SPS7, SPS8 N76H
SP_1837 capsular polysaccharide biosynthesis protein 1,746,914 T C SPS1, SPS9, SPS10 K212R
SP_0117 pspA; pneumococcal surface protein A 118,490 C T SPS9 T23 M
120,431 C A SPS7, SPS8 A670D
118,496 A C SPS7, SPS8, SPS10 Q25P
SP_0799 ciaH; sensor histidine kinase ClaH 753,163 C G SPS7, SPS8 H180D
SP_1923 pln; pneumolysin 1,832,851 G A SPS9 T154 M
SP_0369 penicillin-binding protein 1A 347,479 C T SPS2 E512K
348,706 T A SPS2 T103S
SP_2099 penicillin-binding protein 1B 2,006,807 A G SPS10 V787A
SP_2010 penicillin-binding protein 2A 1,917,863 T C SPS9, SPS10 E17G
1,916,459 T G SPS9 A485E
1,916,166 C T SPS9 A583T
SP_1673 penA; penicillin-binding protein 2B 1,573,212 C A SPS9 L609F
1,574,933 C T SPS3 V36I
1,573,493 C A SPS2 A516S
1,574,288 C A SPS2, SPS3 A251S
1,574,461 G A SPS2 A193V
SP_0336 penicillin-binding protein 2X 308,341 G A SPS9 D488N
307,393 G A SPS2, SPS3 A172T
309,113 C A SPS3 T745 K