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Table 6 Unique non-synonymous single nucleotide polymorphisms (SNPs) associated with penicillin binding proteins (PBPs) and other virulent genes found in all ten pneumococcal isolates isolates

From: Comparative genomic analysis of ten clinical Streptococcus pneumoniae collected from a Malaysian hospital reveal 31 new unique drug-resistant SNPs using whole genome sequencing

Locus Name

Putative Identification

Reference

Position

TIGR4

SNP

Pneumococcal isolate

Amino Acid Change

SP_0346

cpsA; capsular polysaccharide biosynthesis protein

320,234

C

T

SPS7, SPS8, SPS10

A53V

320,204

C

T

SPS7, SPS8

A43V

320,872

C

T

SPS10

P266S

321,451

G

A

SPS10

V459 M

320,657

C

T

SPS9, SPS10

S194 L

321,460

A

G

SPS2

I462V

321,485

T

C

SPS7, SPS8

V470A

320,710

A

G

SPS1

T212A

322,321

A

G

SPS10

K20E

322,360

G

A

SPS2

G33S

323,191

A

C

SPS1, SPS7, SPS8

N76H

SP_1837

capsular polysaccharide biosynthesis protein

1,746,914

T

C

SPS1, SPS9, SPS10

K212R

SP_0117

pspA; pneumococcal surface protein A

118,490

C

T

SPS9

T23 M

120,431

C

A

SPS7, SPS8

A670D

118,496

A

C

SPS7, SPS8, SPS10

Q25P

SP_0799

ciaH; sensor histidine kinase ClaH

753,163

C

G

SPS7, SPS8

H180D

SP_1923

pln; pneumolysin

1,832,851

G

A

SPS9

T154 M

SP_0369

penicillin-binding protein 1A

347,479

C

T

SPS2

E512K

348,706

T

A

SPS2

T103S

SP_2099

penicillin-binding protein 1B

2,006,807

A

G

SPS10

V787A

SP_2010

penicillin-binding protein 2A

1,917,863

T

C

SPS9, SPS10

E17G

1,916,459

T

G

SPS9

A485E

1,916,166

C

T

SPS9

A583T

SP_1673

penA; penicillin-binding protein 2B

1,573,212

C

A

SPS9

L609F

1,574,933

C

T

SPS3

V36I

1,573,493

C

A

SPS2

A516S

1,574,288

C

A

SPS2, SPS3

A251S

1,574,461

G

A

SPS2

A193V

SP_0336

penicillin-binding protein 2X

308,341

G

A

SPS9

D488N

307,393

G

A

SPS2, SPS3

A172T

309,113

C

A

SPS3

T745 K