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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Fig. 4

The blockade of β1-integrin function eliminated thrombomodulin-enhanced VSMCs migration. A7r5 cells transfected with pEGFP, pEGFP-TM or pEGFP-TMS490, 492A were cultured for 36 h and serum-starved for 24 h. A wound healing assay was performed under PDGF treatment for 24 h after pretreating cells with 20 mg/mL of control IgM or anti-β1 integrin antibody, Ha2/5. Cell motility was quantified from at least 3 different experiments and expressed as mean ± SEM. *P < 0.05, compared with the GFP-expressing group; ##P < 0.01, compared with the TM-GFP-expressing group

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