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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Molecular subtyping of nasopharyngeal carcinoma (NPC) and a microRNA-based prognostic model for distant metastasis

Fig. 1

Unsupervised classification identified three molecular distinct subtypes of nasopharyngeal carcinoma. a Unsupervised classification of the training dataset shows the optimal cluster number is three. A classifier was constructed (using 10 unique miRNAs) to categorize patients in each of the subtypes; (b-d) The training dataset (86 patients), GSE32960 set (226 patients) and GSE70970 set (246 patients) were classified into three subtypes according to the classifier, respectively. In the heatmaps, columns correspond to patients, and rows to 10 miRNAs (miR-1248, miR-29b, let-7f, let-7d, miR-26a, miR-200b, miR-370, miR-2053, miR-1293 and miR-622). Expression values are represented by different colors, red means higher expression values, and green for lower expression values. Note: IM is short for immunogenic; (e) A p-value heatmap to represent NPC subtype enriched pathways (normal group was used as control), values in the heatmap equal to -log10 (p-value)

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