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Table 1 Clinical characteristics of patients according to the classifier in the training and validation sets

From: Molecular subtyping of nasopharyngeal carcinoma (NPC) and a microRNA-based prognostic model for distant metastasis

  Training set (n = 86) Internal validation set (n = 226) External validation set (n = 246)
NPC1 (n = 37) NPC2 (n = 33) NPC3 (n = 16) P value* NPC1 (n = 115) NPC2 (n = 75) NPC3 (n = 36) P value* NPC1 (n = 104) NPC2 (n = 93) NPC3 (n = 49) P value*
Age, years 47.03 47.91 48.81 0.4199 47.09 45.88 45.92 0.8134 50.23 51.63 48.07 0.4408
Sex, male 22 (59%) 27 (82%) 13 (81%) 0.0760 86 (75%) 56 (75%) 29 (80%) 0.757 73 (70%) 66 (71%) 36 (73%) 0.9156
WHO pathological type 0.1541 0.5689 NA
 Undifferentiated non-keratinising 0 1 0   2 0 0   NA NA NA  
 Differentiated non-keratinising 1 0 2   3 2 0   NA NA NA  
 Keratinising squamous cell 36 32 14   110 73 36   NA NA NA  
T stage 0.7670 0.5842 0.2508
 T1 13 11 7   22 7 6   32 29 14  
 T2 24 22 9   14 13 7   16 27 8  
 T3 0 0 0   35 26 10   21 19 13  
 T4 0 0 0   44 29 13   35 20 13  
N stage 0.2327 0.797 0.9027
 N0 10 7 1   13 8 5   22 16 11  
 N1 27 26 15   43 26 11   34 35 14  
 N2 0 0 0   37 26 9   37 32 19  
 N3 0 0 0   22 15 11   1 1 2  
TNM stage NA 0.7387 NA
 I 0 0 0   8 2 2   NA NA NA  
 II 37 33 16   0 0 0   NA NA NA  
 III 0 0 0   46 32 13   NA NA NA  
 IV 0 0 0   61 41 21   NA NA NA  
Disease-free survival 0.263a 0.0363a 0.6443a
 Relapses or deaths 5 (14%) 9 (27%) 2 (12%)   40 (28%) 44 (39%) 11 (19%)   37 (36%) 35 (38%) 15 (31%)  
 5 year 86% 73% 88%   72% 61% 81%   64% 62% 69%  
Distant metastasis-free survival 0.0215a 0.0449a 0.0476a
 Distant metastases 0 (0.0%) 6 (18%) 1 (6.0%)   24 (17%) 34 (30%) 8 (13%)   13 (12%) 19 (20%) 3 (6.0%)  
 5-year 100% 82% 94%   83% 70% 87%   88% 80% 94%  
Overall survival 0.6549a 0.1708a 0.5951a
 Deaths 4 (11%) 5 (15%) 1 (6.0%)   32 (23%) 32 (28%) 10 (17%)   29 (28%) 29 (31%) 12 (24%)  
 5-year 89% 85% 94%   77% 72% 83%   82% 69% 76%  
  1. Note: * χ2 test
  2. a Log-rank test