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Table 1 Clinical characteristics of patients according to the classifier in the training and validation sets

From: Molecular subtyping of nasopharyngeal carcinoma (NPC) and a microRNA-based prognostic model for distant metastasis

 

Training set (n = 86)

Internal validation set (n = 226)

External validation set (n = 246)

NPC1 (n = 37)

NPC2 (n = 33)

NPC3 (n = 16)

P value*

NPC1 (n = 115)

NPC2 (n = 75)

NPC3 (n = 36)

P value*

NPC1 (n = 104)

NPC2 (n = 93)

NPC3 (n = 49)

P value*

Age, years

47.03

47.91

48.81

0.4199

47.09

45.88

45.92

0.8134

50.23

51.63

48.07

0.4408

Sex, male

22 (59%)

27 (82%)

13 (81%)

0.0760

86 (75%)

56 (75%)

29 (80%)

0.757

73 (70%)

66 (71%)

36 (73%)

0.9156

WHO pathological type

0.1541

0.5689

NA

 Undifferentiated non-keratinising

0

1

0

 

2

0

0

 

NA

NA

NA

 

 Differentiated non-keratinising

1

0

2

 

3

2

0

 

NA

NA

NA

 

 Keratinising squamous cell

36

32

14

 

110

73

36

 

NA

NA

NA

 

T stage

0.7670

0.5842

0.2508

 T1

13

11

7

 

22

7

6

 

32

29

14

 

 T2

24

22

9

 

14

13

7

 

16

27

8

 

 T3

0

0

0

 

35

26

10

 

21

19

13

 

 T4

0

0

0

 

44

29

13

 

35

20

13

 

N stage

0.2327

0.797

0.9027

 N0

10

7

1

 

13

8

5

 

22

16

11

 

 N1

27

26

15

 

43

26

11

 

34

35

14

 

 N2

0

0

0

 

37

26

9

 

37

32

19

 

 N3

0

0

0

 

22

15

11

 

1

1

2

 

TNM stage

NA

0.7387

NA

 I

0

0

0

 

8

2

2

 

NA

NA

NA

 

 II

37

33

16

 

0

0

0

 

NA

NA

NA

 

 III

0

0

0

 

46

32

13

 

NA

NA

NA

 

 IV

0

0

0

 

61

41

21

 

NA

NA

NA

 

Disease-free survival

0.263a

0.0363a

0.6443a

 Relapses or deaths

5 (14%)

9 (27%)

2 (12%)

 

40 (28%)

44 (39%)

11 (19%)

 

37 (36%)

35 (38%)

15 (31%)

 

 5 year

86%

73%

88%

 

72%

61%

81%

 

64%

62%

69%

 

Distant metastasis-free survival

0.0215a

0.0449a

0.0476a

 Distant metastases

0 (0.0%)

6 (18%)

1 (6.0%)

 

24 (17%)

34 (30%)

8 (13%)

 

13 (12%)

19 (20%)

3 (6.0%)

 

 5-year

100%

82%

94%

 

83%

70%

87%

 

88%

80%

94%

 

Overall survival

0.6549a

0.1708a

0.5951a

 Deaths

4 (11%)

5 (15%)

1 (6.0%)

 

32 (23%)

32 (28%)

10 (17%)

 

29 (28%)

29 (31%)

12 (24%)

 

 5-year

89%

85%

94%

 

77%

72%

83%

 

82%

69%

76%

 
  1. Note: * χ2 test
  2. a Log-rank test