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Table 2 Biodistribution and tumor-to-tissue ratios of 99mTc-HYNIC-(tricine/EDDA)-FROP in MCF-7 female tumor-bearing nude at 15 and 30 min p.i. Data expressed as % ID/g organ

From: 99mTc-HYNIC-(tricine/EDDA)-FROP peptide for MCF-7 breast tumor targeting and imaging

99mTc-HYNIC-FROP

 

%ID/g

 

15 min

30 min

Block-15 min

Tissue

 Blood

0.48 ± 0.09

0.35 ± 0.10

0.69 ± 0.16

 Heart

0.49 ± 0.08

0.26 ± 0.11

0.45 ± 0.03

 Lung

0.45 ± 0.08

0.41 ± 0.26

0.60 ± 0.04

 S.Ta

0.25 ± 0.03

0.32 ± 0.22

0.25 ± 0.01

 Liver

0.20 ± 0.02

0.14 ± 0.00

0.26 ± 0.04

 Spleen

0.15 ± 0.01

0.28 ± 0.11

0.23 ± 0.07

 Kidney

2.22 ± 0.16

1.73 ± 0.15

2.97 ± 0.23

 Stomach

0.21 ± 0.01

0.33 ± 0.12

0.26 ± 0.01

 Muscle

0.08 ± 0.01

0.21 ± 0.16

0.15 ± 0.01

 Bone

0.18 ± 0.02

0.24 ± 0.12

0.22 ± 00

 Intestine

0.34 ± 0.09

0.79 ± 0.25

0.64 ± 0.09

 Tumor

0.25 ± 0.02

0.38 ± 0.21

0.09 ± 0.02

Tumor/Tissue

 Muscle

3.03 ± 0.12

1.94 ± 0.46

0.60 ± 0.12

 Blood

0.53 ± 0.15

1.09 ± 0.47

0.14 ± 0.06

 Spleen

1.61 ± 0.22

1.56 ± 1.04

0.42 ± 0.14

 Bone

1.36 ± 0.28

1.57 ± 0.48

0.40 ± 0.09

 Liver

1.24 ± 0.28

2.62 ± 1.38

0.36 ± 0.13

  1. aSalivary Gland and Thyroid