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Table 2 Biodistribution and tumor-to-tissue ratios of 99mTc-HYNIC-(tricine/EDDA)-FROP in MCF-7 female tumor-bearing nude at 15 and 30 min p.i. Data expressed as % ID/g organ

From: 99mTc-HYNIC-(tricine/EDDA)-FROP peptide for MCF-7 breast tumor targeting and imaging

99mTc-HYNIC-FROP
  %ID/g
  15 min 30 min Block-15 min
Tissue
 Blood 0.48 ± 0.09 0.35 ± 0.10 0.69 ± 0.16
 Heart 0.49 ± 0.08 0.26 ± 0.11 0.45 ± 0.03
 Lung 0.45 ± 0.08 0.41 ± 0.26 0.60 ± 0.04
 S.Ta 0.25 ± 0.03 0.32 ± 0.22 0.25 ± 0.01
 Liver 0.20 ± 0.02 0.14 ± 0.00 0.26 ± 0.04
 Spleen 0.15 ± 0.01 0.28 ± 0.11 0.23 ± 0.07
 Kidney 2.22 ± 0.16 1.73 ± 0.15 2.97 ± 0.23
 Stomach 0.21 ± 0.01 0.33 ± 0.12 0.26 ± 0.01
 Muscle 0.08 ± 0.01 0.21 ± 0.16 0.15 ± 0.01
 Bone 0.18 ± 0.02 0.24 ± 0.12 0.22 ± 00
 Intestine 0.34 ± 0.09 0.79 ± 0.25 0.64 ± 0.09
 Tumor 0.25 ± 0.02 0.38 ± 0.21 0.09 ± 0.02
Tumor/Tissue
 Muscle 3.03 ± 0.12 1.94 ± 0.46 0.60 ± 0.12
 Blood 0.53 ± 0.15 1.09 ± 0.47 0.14 ± 0.06
 Spleen 1.61 ± 0.22 1.56 ± 1.04 0.42 ± 0.14
 Bone 1.36 ± 0.28 1.57 ± 0.48 0.40 ± 0.09
 Liver 1.24 ± 0.28 2.62 ± 1.38 0.36 ± 0.13
  1. aSalivary Gland and Thyroid