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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Molecular mechanisms underlying therapeutic potential of pericytes

Fig. 1

Markers of pericytes identification. Due to the heterogeneity of pericytes, several markers were usually used for their identification such as platelet-derived growth factor receptor β (PDGFRβ): receptor with tyrosin kinase activity, involved in pericytes proliferation and recruitment; nerve-glial antigen-2 (NG2): membrane chondroitin sulfate proteoglycan involved in pericyte recruitment to tumor vasculature; CD146: transmembrane glycoprotein that functions as a Ca2 + −independent cell adhesion molecule; the regulator of G-protein signaling-5 (RGS5): a GTPase-activating protein, expressed on activated pericytes during vessel remodeling and tumor development; α-smooth muscle actin (α-SMA) and desmin: structural proteins, important for pericyte contraction and regulation of blood pressure; aminopeptidase N (CD13): membrane zinc-dependent metalloprotease, expressed mainly on brain pericytes; glioma-associated oncogene (Gli1): zinc finger protein, effector of Hedgehog signaling pathway, involved in pericyte-mediated modulation of fibrosis and in the maintenance of peritubular capillary health and T-box transcription factor TBX18 (Tbx18): involved in the development of the heart and coronary vessels

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