Table 1 Functional characterization of MIAT in diseases
From: Long non-coding RNA MIAT in development and disease: a new player in an old game
Disease type | Expression | Function | Related gene | Tissue | Animal | Role | Ref |
|---|---|---|---|---|---|---|---|
Myocardial infarction | Up | Proliferation | miR-24/Furin/TGF-β1 | Cardiac | Mouse | Pathogenesis | 18, 31, 32 |
Schizophrenia | Down | Differention, maintenance | QKI/SRSF1/DISC1/ERBB4/DRD2/GRM3 | Brain | Mouse | Pathogenesis | 40–42 |
Ischemic stroke | Up | N.D. | N.D. | Blood | N.D. | Pathogenesis | 37 |
Diabetic cardiomyopathy | Up | Apoptosis | miR-22-3p/DAPK2 | Cardiac | Rat | Pathogenesis | 56 |
Diabetic nephropathy | Down | Viability | Nrf2 | Kidney | Rat | Pathogenesis | 57 |
Cataract | Up | Proliferation, apoptosis Migration | miR-150-5p/Akt | Eye | N.D. | Pathogenesis | 58 |
Bone disease | Down | Migration | N.D. | Adipose | N.D. | Pathogenesis | 59 |
Chronic chagas disease cardiomyopathy | Up | N.D. | N.D. | Heart | Mouse | Pathogenesis | 60 |
Chronic lymphocytic leukemia | Up | Proliferation Apoptosis | OCT4 | Blood | N.D. | Pathogenesis | 61 |
Neuroendocrine prostate cancer | Up | N.D. | N.D. | Prostate | N.D. | Oncogenic | 47 |
Non-small-cell lung cancer | Up | Invasion | miR-150/ZEB1 | Lung | N.D. | Oncogenic | 52 |