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Table 1 Functional characterization of MIAT in diseases

From: Long non-coding RNA MIAT in development and disease: a new player in an old game

Disease type Expression Function Related gene Tissue Animal Role Ref
Myocardial infarction Up Proliferation miR-24/Furin/TGF-β1 Cardiac Mouse Pathogenesis 18, 31, 32
Schizophrenia Down Differention, maintenance QKI/SRSF1/DISC1/ERBB4/DRD2/GRM3 Brain Mouse Pathogenesis 40–42
Ischemic stroke Up N.D. N.D. Blood N.D. Pathogenesis 37
Diabetic cardiomyopathy Up Apoptosis miR-22-3p/DAPK2 Cardiac Rat Pathogenesis 56
Diabetic nephropathy Down Viability Nrf2 Kidney Rat Pathogenesis 57
Cataract Up Proliferation, apoptosis
Migration
miR-150-5p/Akt Eye N.D. Pathogenesis 58
Bone disease Down Migration N.D. Adipose N.D. Pathogenesis 59
Chronic chagas disease cardiomyopathy Up N.D. N.D. Heart Mouse Pathogenesis 60
Chronic lymphocytic leukemia Up Proliferation
Apoptosis
OCT4 Blood N.D. Pathogenesis 61
Neuroendocrine prostate cancer Up N.D. N.D. Prostate N.D. Oncogenic 47
Non-small-cell lung cancer Up Invasion miR-150/ZEB1 Lung N.D. Oncogenic 52
  1. Abbreviation: N.D. Not determined, TGF-β1 transforming growth factor β1, QKI quaking homolog, DISC1 disrupted in schizophrenia 1, ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4, DAPK2 Death Associated Protein Kinase 2