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Table 1 Mitochondrial transfer from Different Tissue Specific MSCs to Recipient Cells of Different Origins

From: Regenerative abilities of mesenchymal stem cells through mitochondrial transfer

S. No

MSCs Type

Recipient Cell

Mode of Transfer

Action

References

1

BM-MSCs

A549 Cell Line

Cellular Contact and Cytoplasmic Projections

Restored Aerobic Respiration

[8]

2

BM-MSCs

Pulmonary Alveoli in mouse lungs

Connexin43 alveolar attachment and microvesicles

Protection against acute lung injury

[15]

3

BM-MSCs and iPSCs

Airway epithelial cells

Tunnel Tubes

Rescue cigarettesmoke induced damage

[20]

4

BM-MSCs

Bronchial Epithelial Cells

Tunnel Tubes and Miro1

Rescue Bronchial Epithelial Injury

[21]

5

BM-MSCs

H9c2 cardiomyocyte cell line

Tunnel Tubes

Rescue cardiomyocytes in ischemia model

[22]

6

BM-MSCs

Cardiomyocytes

Tunnel Tubes

Repair damaged cardiomyocytes in failed myocardium

[23]

7

BM-MSCs

Cardiomyoblasts

Cell-Cell Connection and Tubular Connections

Rescue Cells from Ischemic Damage

[24]

8

BM-MSCs

Kidney Tubular Epithelial cells

Microvesicles

Recovery from acute kidney injury

[25]

9

BM-MSCs

Rat Cortical Neuronal Cells

Tunnel Tubes and Miro1

Neuroprotective

[26]

10

BM-MSCs

Macrophages

Tunnel Tubes

Anti-Bacterial Activity

[27]

11

BM-MSCs

Macrophages

Extracellular Vesicles

Regulation of mitochondrial dynamics and Mitophagy

[28]

12

BM-MSCs

Acute myeloid leukemic cells

Cell-Cell Contact

Survival of Myeloid Cells

[18]

13

BM-MSCs

MDA-MB231 breast carcinoma cell line

Isolated mitochondria

Enhanced OXPHOS activity

[29]

14

iPSCs-MSCs

Corneal Epithelial Cells

Tunnel Tubes

Protection of corneal epithelial cells against alkali burn

[16]

15

AD- MSCs

Cardiomyocytes

Cell Fusion

Reprogram adult cardiac cells towards progenitor like state

[30]

16

WJ-MSCs

Cells devoid of mitochondria Osteosarcoma cells

Tunnel Tubes

Mitochondria function was rescued

[19]