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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Fig. 1

Antiproliferative effect of MPT0B098 in OEC-M1 cells under normoxic and hypoxic conditions. a The chemical structure of MPT0B098. b The in vitro antiproliferative activity of MPT0B098 in OEC-M1 cells under normoxic and hypoxic conditions. OEC-M1 cells were treated with MPT0B098, colchicine, or paclitaxel under normoxic and hypoxic conditions for 72 h. The IC50 values of these compounds resulting from 50% inhibition of cell growth were calculated using the methylene blue dye assay. Each value represents the mean ± SD of three independent experiments. c Hypoxia-induced drug resistance is the IC50 value of the test compounds in hypoxia divided by the equivalent in normoxia (* p < 0.05)

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