Fig. 4
MPT0B098 suppresses hypoxia-induced EMT by inhibiting the expression of EMT-activating transcription factors, Twist and SNAI2/Slug. a The effects of MPT0B098 on the expression of Twist and SNAI2/Slug in OEC-M1 cells.OEC-M1 cells were treated with various concentrations, indicated as fold of IC50 values, of MPT0B098 for 18 and 36 h under hypoxic conditions. At the end of the drug treatment, cell lysates were prepared and analyzed by SDS-PAGE and Western blot. GAPDH was used as an internal control. Each values depicts the mean of the relative intensities of Twist and SNAI2/Slug from three independent experiments. b Each value depicts the mean of the relative intensities of Twist and SNAI2/Slug from three independent experiments (* p < 0.05, compared to hypoxia control)