Fig. 8

MPT0B098 inhibits hypoxia-induced cell migration in OEC-M1 cells. a Effect of MPT0B098 on cell motility. OEC-M1 cells were treated with 0.5-fold IC₅₀ of MPT0B098 for 8 h and then cell motility was determined by the wound healing assay. b Quantification of cell migration was carried out by measuring the wound area (left panel) and calculating cell viability (right panel) after cells were treated with 0.5-fold IC₅₀ of MPT0B098 for 4, 6, 8, and18 h. c Parallel comparison of the effect of MPT0B098 with other microtubule inhibitors, including colchicine and paclitaxel, at the drug concentration of 0.5-fold IC₅₀on cell motility (left panel) and viability (right panel) at a treatment duration of 8 h. Data are represented as mean ± SD in triplicate. **P < 0.01 and ***P < 0.001 for comparison between the control and treatment groups using an unpaired two-tailed Student’s t test