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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation

Fig. 5

SP110-mediated down-regulation of NF-κB activity is independent of GSK3β. HEK293T cells were co-transfected with pGL3-TNFα promoter-F.Luc, pSV40-R.Luc, and the indicated constructs, and cultured in the absence or presence of GSK3β inhibitor. The relative Luc values for the TNFα promoter were then measured 2 days after co-transfection. The empty vector negative control is shown at the top. The data are presented as the mean ± SD. Statistical significance of the difference between two sample groups was calculated using a two-tailed unpaired t-test. **P < 0.01; ***P < 0.001. The data represent 3 independent experiments

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