Toll-like receptors in lupus nephritis

Table 1 Various TLR polymorphisms studied in SLE and LN patients

TLR	Allele	Ethnicity/year of study	Association
TLR2	rs1816702,rs4235232	multiethnic group,2014	positive [149]
TLR2	R753Q	South Indians,2015	positive [150]
TLR3	rs3775296-T	Taiwanese,2014	positive [26]
	rs3775291	Danish,2014	positive [151]
	rs3775291	Meta analysis, 2016	No association [60]
TLR4	D299G,T399I	Meta analysis 2016	positive [152]
	rs4986790,rs4986791	Meta analysis, 2016	No association [60]
	D299G,T399I	South Indian cohort,2015	positive [16]
	1196 C/T	Polish population,2013	Negative [153]
TLR5	rs5744168	American^a,2017	No association [19]
TLR5	rs5744168	Zhuang and Han ethnics,2015	No association [154]
TLR7	PTPN22 Variant R620W	American^a,2015	positive [155]
	rs3853839	Danish,2014	positive [156]
	s3853839-G,rs3853839,rs179010-T	Taiwanese,2014	positive [26]
	rs3853839	Mutliethnic group,2013	positive [157]
TLR8	rs3764880-G,rs3764880	Taiwanese,2014	positive [26]
	rs3764879	Danish,2014	positive [156]
	rs37648	Danish,2014	positive [151]
TLR9	rs352143	Danish,2014	positive [151]
	rs352140	American^a,2017	positive [19]
	rs352140	Zhuang and Han ethnics,2015	positive [154]
	PTPN22 rs2476601	Meta analysis,2017	positive [158]
	rs187084	South Indians,2017	positive [159]
	rs352139	Egyptian,2016	positive [160]
	-1237C/T	South Indians,2015	positive [150]
	T-1237C and T-1486C	Meta analysis,2013	negative [161]
	rs352140, rs5743836,rs352139	Meta analysis, 2016	negative [60]

^aethnicity was not clear; study information was restricted for the last five years

ISSN: 1423-0127