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Table 1 Ceramide and Sphingomyelin in Skeletal Muscle: Levels of ceramide and sphingomyelin (nmol/g tissue wet weight) in the rat skeletal muscle (gastrocnemius) following acute administration of olanzapine (1 mg/kg), clozapine (12 mg/kg) or vehicle (control). Data presented as mean ± SEM, (n = 6–7/group)

From: Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

  Control Olanzapine Clozapine
Ceramide
 Total 49.08 ± 1.19 33.96 ± 6.03 47.65 ± 2.81
 Cer 16:0 3.96 ± 0.72 2.05 ± 0.38 3.77 ± 1.02
 Cer 18:0 22.71 ± 1.84 18.75 ± 2.50 24.77 ± 0.91
 Cer 19:0 0.79 ± 0.03 0.60 ± 0.17 0.82 ± 0.07
 Cer 20:0 3.40 ± 0.11 2.93 ± 0.27 2.33 ± 0.33
 Cer 22:0 3.35 ± 0.40 3.28 ± 0.32 2.65 ± 0.28
 Cer 22:1 0.31 ± 0.15 0.20 ± 0.10 0.37 ± 0.14
 Cer 23:0 2.17 ± 0.29 2.14 ± 0.03 1.66 ± 0.23
 Cer 24:0 7.08 ± 0.97 6.71 ± 0.68 6.08 ± 0.93
 Cer 24:1 5.32 ± 0.40 3.46 ± 0.23 4.49 ± 0.70
 Cer 24:2 0.84 ± 0.10 0.44 ± 0.21 0.71 ± 0.17
 Cer 25:0 0.30 ± 0.14 0.31 ± 0.14 0.30 ± 0.15
Sphingomyelin
 Total 521.23 ± 20.74 409.07 ± 69.83 472.09 ± 17.39
 SM 16:0 59.07 ± 12.48 51.95 ± 9.07 64.12 ± 8.68
 SM 17:0 5.98 ± 0.45 5.35 ± 0.23 5.91 ± 0.48
 SM 18:0 241.68 ± 10.63 213.19 ± 20.40 253.40 ± 9.12
 SM 18:1 11.29 ± 0.59 9.44 ± 1.29 10.44 ± 0.39
 SM 19:1 4.78 ± 0.18 4.57 ± 0.22 4.78 ± 0.18
 SM 20:0 25.45 ± 3.31 23.43 ± 2.63 15.27 ± 1.61
 SM 22:0 37.96 ± 5.27 43.44 ± 6.70 23.39 ± 2.75
 SM 22:1 4.51 ± 0.98 4.68 ± 1.09 2.68 ± 0.88
 SM 23:0 14.60 ± 1.48 18.36 ± 2.68 10.25 ± 1.09
 SM 24:0 42.86 ± 4.73 48.30 ± 7.24 29.11 ± 2.39
 SM 24:1 66.81 ± 8.28 49.84 ± 2.33 45.62 ± 4.91
 SM 24:2 8.69 ± 0.58 7.06 ± 0.25 7.12 ± 1.02