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Table 1 Ceramide and Sphingomyelin in Skeletal Muscle: Levels of ceramide and sphingomyelin (nmol/g tissue wet weight) in the rat skeletal muscle (gastrocnemius) following acute administration of olanzapine (1 mg/kg), clozapine (12 mg/kg) or vehicle (control). Data presented as mean ± SEM, (n = 6–7/group)

From: Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration

 

Control

Olanzapine

Clozapine

Ceramide

 Total

49.08

±

1.19

33.96

±

6.03

47.65

±

2.81

 Cer 16:0

3.96

±

0.72

2.05

±

0.38

3.77

±

1.02

 Cer 18:0

22.71

±

1.84

18.75

±

2.50

24.77

±

0.91

 Cer 19:0

0.79

±

0.03

0.60

±

0.17

0.82

±

0.07

 Cer 20:0

3.40

±

0.11

2.93

±

0.27

2.33

±

0.33

 Cer 22:0

3.35

±

0.40

3.28

±

0.32

2.65

±

0.28

 Cer 22:1

0.31

±

0.15

0.20

±

0.10

0.37

±

0.14

 Cer 23:0

2.17

±

0.29

2.14

±

0.03

1.66

±

0.23

 Cer 24:0

7.08

±

0.97

6.71

±

0.68

6.08

±

0.93

 Cer 24:1

5.32

±

0.40

3.46

±

0.23

4.49

±

0.70

 Cer 24:2

0.84

±

0.10

0.44

±

0.21

0.71

±

0.17

 Cer 25:0

0.30

±

0.14

0.31

±

0.14

0.30

±

0.15

Sphingomyelin

 Total

521.23

±

20.74

409.07

±

69.83

472.09

±

17.39

 SM 16:0

59.07

±

12.48

51.95

±

9.07

64.12

±

8.68

 SM 17:0

5.98

±

0.45

5.35

±

0.23

5.91

±

0.48

 SM 18:0

241.68

±

10.63

213.19

±

20.40

253.40

±

9.12

 SM 18:1

11.29

±

0.59

9.44

±

1.29

10.44

±

0.39

 SM 19:1

4.78

±

0.18

4.57

±

0.22

4.78

±

0.18

 SM 20:0

25.45

±

3.31

23.43

±

2.63

15.27

±

1.61

 SM 22:0

37.96

±

5.27

43.44

±

6.70

23.39

±

2.75

 SM 22:1

4.51

±

0.98

4.68

±

1.09

2.68

±

0.88

 SM 23:0

14.60

±

1.48

18.36

±

2.68

10.25

±

1.09

 SM 24:0

42.86

±

4.73

48.30

±

7.24

29.11

±

2.39

 SM 24:1

66.81

±

8.28

49.84

±

2.33

45.62

±

4.91

 SM 24:2

8.69

±

0.58

7.06

±

0.25

7.12

±

1.02