Fig. 2

Distinct NGS-derived SNVs located in HBV regulatory element and ORFs associated with HCC among patients with genotype B and genotype C. a, Twenty-five distinct NGS-defined HCC-associated SNVs were located in HBV regulatory elements and ORFs for genotype B HBV. b, Thirty five distinct NGS-defined HCC-associated SNVs were located in HBV regulatory elements and ORFs for genotype C HBV. * and ** indicate risk of SNVs for HCC with an odds ratio of HCC > 1 and with P value of < 0.05 and < 0.01, respectively. Ɨ means protective SNVs for HCC with an odds ratio of HCC < 1 and with a P value < 0.05. ● missense mutation; ○ silent mutation; • SNVs located in regulatory element. Level A means HCC-associated HBV variants supported by meta-analysis with at least 4 studies. Level B means HCC-associated HBV variants supported by at least one study if total number of relevant studies is less than 4. Level C means HBV variants unassociated with HCC supported by all studies if total number of relevant studies is less than 4. Red box indicated Level A; Blue box indicated Level B; Yellow box indicated Level C. The figure has been adopted from [70]