Fig. 3

The distribution of SNV frequencies in SNV I and SNV II. Almost all SNV I had SNV frequencies higher than 80%. The great majority of SNV II had either low (< 20%) or high (> 80%) SNV frequencies, i.e. a characteristic U-shaped distribution pattern of SNV frequencies with low (< 20%) or high (> 80%) values. a, All SNVs in genotype B HCC group. b, All SNVs in genotype B non-HCC group. c, All SNVs in genotype C HCC group. d, All SNVs in genotype C non-HCC group. SNV I was defined as the dominant strain of HBV in non-HCC group. SNV II was defined as the variant other than SNV I at the same nucleotide position, i.e. the minor strain of HBV in non-HCC group