Fig. 4From: Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutationsThe distribution of pathogenic frequencies in HCC-associated SNV I and SNV II. Almost all HCC-associated SNV I had pathogenic frequencies higher than 80% and the great majority of HCC-associated SNV II had either low (< 20%) or high (> 80%) pathogenic frequencies, i.e. a U-shaped distribution pattern. SNV I was defined as the dominant strain of HBV in non-HCC group. SNV II was defined as the variant other than SNV I at the same nucleotide position, i.e. the minor strain of HBV in non-HCC groupBack to article page