Fig. 2From: MARCKS and MARCKS-like proteins in development and regenerationMolecular interactions of MARCKS. Role of membrane- tethered, unphosphorylated MARCKS (a1-d1) is compared with its cytosolic, phosphorylated form (a2-d2). Membranes are depicted in grey; phosphorylation is indicated by purple circles. a Direct actin binding of unphosphorylated MARCKS. b PIP2 sequestration of unphosphorylated MARCKS; upon phosphorylation of MARCKS, PIP2 becomes accessible to PLC and PI3K. c Phosphorylated MARCKS binds to Tob resulting in activation of ErbB2 signalling. d Unphosphorylated MARCKS binds to Rab10 promoting exocytosis of vesicles. See text for detailsBack to article page