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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+/Ca2+ exchanger and mitochondria in the rat suprachiasmatic nucleus neurons

Fig. 1

High K+-induced membrane depolarizations and voltage dependence of Ca2+ channels. a Voltage responses to 20 (left panel) and 50 (right panel) mM K+ solution from a representative SCN neuron recorded with the perforated patch technique. b Family of calcium currents activated from a holding potential of − 87 mV recorded with the whole-cell technique. Lower panel: voltage-clamp protocol. Horizontal dotted line was the zero current level. c Summary of experiments showing the I-V relation. The Ca2+ current amplitude was measured by taking the average near the end of 20-ms step. Each data point represents the mean ± SEM of 9 cells. Arrows marked the average membrane potentials at rest (downward arrow) and in response to 20 mM (slant arrow) and 50 mM (horizontal arrow) K+

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