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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+/Ca2+ exchanger and mitochondria in the rat suprachiasmatic nucleus neurons

Fig. 4

Concentration-dependent effects of nimodipine on 20 K+-induced Ca2+ transients (a, b), basal [Ca2+]i (c, d), and spontaneous firing (e, f). a A representative experiment showing the averaged Ca2+ response (n = 20 cells) to 20 mM K+ for 20 s in control and in increasing concentrations of nimodipine. b Statistics showing the concentration-dependent percent block by nimodipine of 20 K+-induced Ca2+ responses (n = 260 cells). c A representative experiment showing the averaged Ca2+ response (n = 20 cells) to Ca2+-free solution and increasing concentrations of nimodipine. d Statistics showing the concentration-dependent percent block by nimodipine of basal Ca2+ influx as determined by Ca2+-free (0-Ca2+) solution (n = 344 cells). e The time course of change in spontaneous firing rate (SFR) of a representative cell in response to increasing concentrations of nimodipine. Insets show the cell-attached recording of firing responses to 0.2, 2, and 20 μM nimodipine. Note that 20 μM, but not 0.2 or 2 μM, nimodipine inhibited the spontaneous firing. f Statistics showing the concentration-dependent percent block by nimodipine of spontaneous firing (n = 20 cells). *** P < 0.001

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