Fig. 4
From: Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
Approaches and mechano-gating mechanisms of the “bilayer model” and “tether model” of mechanically activated ion channels. a Direct neurite indentation by using a blunt pipette alters membrane tension and thus opens the mechanically activated ion channel of the bilayer model (e.g., PIEZO2). b Substrate deformation-driven neurite stretch acts on channel-tethering proteins of the extracellular matrix and cytoskeletons and thus opens the mechanically activated ion channels of the tether model (e.g., MEC-4/MEC-10 or ASICs)