Table 3 Effects of ASIC-subtype knockout on neurological disorders
From: Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
| Â | ASIC1a KO | ASIC2 KO | ASIC3 KO | ASIC4 KO | References |
|---|---|---|---|---|---|
Ischemic stroke | Reduced ischemic brain injury [46]; Reduced acidosis-induced neuronal cell death [131] | NA | NA | NA | |
Learning and memory | Impaired fear memory [44]; Impaired spatial memory [133]; No effect on spatial memory [134] | NA | No effect [37] | No effect [44] | |
Multiple sclerosis | No effects [129] | No effect [129] | NA | ||
Epilepsy | Impaired seizure termination and increase kanic acid-induced seizure [44, 53] | NA | NA | No effect [44] | |
Anxiety / Fear / Depression /Aggression | Reduced fear and anxiety-like behaviors [51] | NA | Reduced anxiety-like and aggression-like behaviors; no effect on depression-like behaviors [37] | Increased fear and anxiety-like behaviors [44] | |
Addition | Increased condition place preference to cocaine and morphine [52]; Increase amphetamine-induced hyperlocomotion, behavioral sensitization, and rewarding [44] | No effect [132] | NA | No effect [44] | |
Neuropathic pain | No effect [129] | No effect [129] | NA | ||
Fibromyalgia | No effect [61] | NA | No pain developed [61] | NA | [61] |
Rheumatic arthritis | Abolished primary hyperalgesia, [42] | NA | Abolished secondary hyperalgesia [42] | NA | [42] |
Hearing | NA | Resistant to noise-induced threshold shift [31] | NA |