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Table 3 Effects of ASIC-subtype knockout on neurological disorders

From: Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

  ASIC1a KO ASIC2 KO ASIC3 KO ASIC4 KO References
Ischemic stroke Reduced ischemic brain injury [46]; Reduced acidosis-induced neuronal cell death [131] NA NA NA [46, 131]
Learning and memory Impaired fear memory [44]; Impaired spatial memory [133]; No effect on spatial memory [134] NA No effect [37] No effect [44] [37, 44, 133, 134]
Multiple sclerosis Reduced EAE-induced clinical symptoms [48, 129, 130] No effects [129] No effect [129] NA [48, 129, 130]
Epilepsy Impaired seizure termination and increase kanic acid-induced seizure [44, 53] NA NA No effect [44] [44, 53]
Anxiety / Fear / Depression /Aggression Reduced fear and anxiety-like behaviors [51] NA Reduced anxiety-like and aggression-like behaviors; no effect on depression-like behaviors [37] Increased fear and anxiety-like behaviors [44] [37, 44, 51]
Addition Increased condition place preference to cocaine and morphine [52]; Increase amphetamine-induced hyperlocomotion, behavioral sensitization, and rewarding [44] No effect [132] NA No effect [44] [44, 52, 132]
Neuropathic pain No effect [128, 129] No effect [129] No effect [129] NA [128, 129]
Fibromyalgia No effect [61] NA No pain developed [61] NA [61]
Rheumatic arthritis Abolished primary hyperalgesia, [42] NA Abolished secondary hyperalgesia [42] NA [42]
Hearing NA Resistant to noise-induced threshold shift [31] Age-dependent hearing loss to ultrasound [74, 74] NA [74, 75]
  1. NA not available