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Table 2 Summary of perinatal Pb2+ exposure results on developmental time-points altering the expression of genes related to the GABA-shift, when compared to the Control group

From: Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats

 

PFC Pb 2+ Effects

HP Pb 2+ Effects

Genes

PND 2

PND 7

PND 14

PND 22

PND 2 PND 7

PND 14

PND22

Caβ3

↑

↑

↓

↓

↔

↓

↓

↓

n/s

‡‡

‡‡

‡‡

n/s

‡‡

‡‡

‡‡

     

###

###

###

GABA-β3

↑

↑

↔

↓

↔

↓

↓

↓

‡‡

‡‡

n/s

‡‡

n/s

###

###

###

##

##

 

##

    

NKCC1

↑

↑

↔

↔

↑

↓

↔

↓

##

##

n/s

n/s

n/s

n/s

n/s

n/s

KCC2

↑

↔

↑

↔

↓

↓

↑

↔

n/s

n/s

n/s

n/s

#

#

##

n/s

GAD-80

↑

↔

↑

↔

↓

↔

↑

↔

#

n/s

#

n/s

‡‡‡

n/s

‡‡‡

n/s

GAD-86

↑

↔

↑

↔

↑

↔

↑

↔

###

n/s

###

n/s

n/s

n/s

n/s

n/s

GAD-65

↔

↑

↔

↓

↓

↓

↔

↔

n/s

‡‡‡

n/s

‡‡‡

#

#

n/s

n/s

GAD-67

↑

↑

↑

↓

↔

↓

↔

↓

n/s

n/s

‡‡‡

‡‡‡

n/s

n/s

n/s

‡‡‡

       

###

  1. Note: Difference in expression of mRNAs are summarized as (↑) = an increase in mRNA, (↓) = a decrease in mRNA, and (↔) = no difference in relative mRNA expression. Tukey’s post hoc analyses are denoted as a significant difference between Pb2+ vs. Control as a function of Treatment (p < 0.05#, p < 0.01##, p < 0.001###) and an Age X Treatment interaction (p < 0.05‡, p < 0.01‡‡, p < 0.001‡‡‡) for each developmental time-point, whereas (n/s) = not significant