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Table 2 Summary of perinatal Pb2+ exposure results on developmental time-points altering the expression of genes related to the GABA-shift, when compared to the Control group

From: Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats

  PFC Pb 2+ Effects HP Pb 2+ Effects
Genes PND 2 PND 7 PND 14 PND 22 PND 2 PND 7 PND 14 PND22
Caβ3
n/s ‡‡ ‡‡ ‡‡ n/s ‡‡ ‡‡ ‡‡
      ### ### ###
GABA-β3
‡‡ ‡‡ n/s ‡‡ n/s ### ### ###
## ##   ##     
NKCC1
## ## n/s n/s n/s n/s n/s n/s
KCC2
n/s n/s n/s n/s # # ## n/s
GAD-80
# n/s # n/s ‡‡‡ n/s ‡‡‡ n/s
GAD-86
### n/s ### n/s n/s n/s n/s n/s
GAD-65
n/s ‡‡‡ n/s ‡‡‡ # # n/s n/s
GAD-67
n/s n/s ‡‡‡ ‡‡‡ n/s n/s n/s ‡‡‡
        ###
  1. Note: Difference in expression of mRNAs are summarized as (↑) = an increase in mRNA, (↓) = a decrease in mRNA, and (↔) = no difference in relative mRNA expression. Tukey’s post hoc analyses are denoted as a significant difference between Pb2+ vs. Control as a function of Treatment (p < 0.05#, p < 0.01##, p < 0.001###) and an Age X Treatment interaction (p < 0.05, p < 0.01‡‡, p < 0.001‡‡‡) for each developmental time-point, whereas (n/s) = not significant