Table 3 Multivariate analyses for progression-free and overall survival in lung adenocarcinoma
From: Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma
Variable | High membranous EGFR | High nuclear EGFR | |||||||
|---|---|---|---|---|---|---|---|---|---|
Parameter | No | PFS | OS | PFS | OS | ||||
aHR (95%CI) | p | aHR (95%CI) | p | bHR (95%CI) | p | bHR (95%CI) | p | ||
All patients | 161 | 0.72 (0.50~ 1.04) | 0.078 | 0.70 (0.47~ 1.03) | 0.071 | 0.89 (0.61~ 1.29) | 0.529 | 0.72 (0.49~ 1.07) | 0.103 |
Older age (> 70 yr) | 84 | 0.60 (0.36~ 0.99) | 0.046 | 0.55 (0.32~ 0.92) | 0.023 | 0.77 (0.47~ 1.27) | 0.310 | 0.62 (0.37~ 1.05) | 0.077 |
Smokers | 58 | 0.63 (0.34~ 1.16) | 0.135 | 0.51 (0.26~ 0.98) | 0.045 | 0.64 (0.34~ 1.21) | 0.166 | 0.49 (0.25~ 0.97) | 0.041 |
Distant (metastasis) | 94 | 1.20 (0.76~ 1.88) | 0.434 | 1.00 (0.63~ 1.61) | 0.985 | 1.68 (1.05~ 2.68) | 0.030 | 1.27 (0.77~ 2.08) | 0.350 |
No brain metastasis | 114 | 0.56 (0.34~ 0.91) | 0.018 | 0.56 (0.33~ 0.94) | 0.028 | 0.86 (0.54~ 1.36) | 0.521 | 0.72 (0.44~ 1.18) | 0.186 |
Wildtype EGFR | 74 | 0.49 (0.28~ 0.85) | 0.012 | 0.51 (0.29~ 0.90) | 0.019 | 0.73 (0.43~ 1.24) | 0.240 | 0.62 (0.36~ 1.08) | 0.092 |