Fig. 2From: LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson’s disease: a reviewSummary of the putative mechanisms of mutations in the LRRK2 ROCO domain. Data indicate that mutations in the LRRK2 ROC domain through the alteration of kinase and/or GTPase activity can affect mitochondrial function, the ubiquitin-proteasome system, the autophagy-lysosomal pathway, and the trafficking of vesicles and proteinsBack to article page