Fig. 1

Deletion of ST2 accelerates CLP induced polymicrobial sepsis and affects granulocytes influx into peritoneal cavity. Clinical score and survival rate of septic ST2^−/− and WT mice was monitored every 6 h. a ST2^−/− mice exhibit significantly increased clinical score during first 18 h following CLP. b Survival rate of septic ST2^−/− and WT mice was analyzed by Fisher’s exact test for each time point. ST2^−/− mice had significantly decreased survival rate at 36, 42 and 48 h following CLP (n = 22 mice per group). c Significantly decreased number of peritoneal cells in septic ST2^−/− in comparison with WT mice 12 h following CLP. The number of peritoneal neutrophils (CD11b⁺Ly6G⁺) (d), eosinophils (CD11b⁺Siglec-F⁺) (e), mast cells (CD117⁺FcεRI⁺) (f) and macrophages (g) 12 h following CLP. Data are presented as mean ± SE, n = 4–7 mice per group. *p < 0.05, **p < 0.01