Skip to main content

Table 3 Chemical compounds identified by Connectivity map and list the top 20 ranked by P-value

From: Identification of target genes in cardiomyopathy with fibrosis and cardiac remodeling

rank cmap name Mean n enrichment P-value
1 tridihexethyl −0.64 4 − 0.883 0.00044
2 Prestwick-682 −0.509 4 −0.848 0.00097
3 fluoxetine −0.494 4 −0.806 0.00271
4 pirlindole −0.668 3 −0.884 0.00312
5 methyldopa 0.382 5 0.732 0.00318
6 ciclacillin 0.494 4 0.789 0.00391
7 sulfadiazine 0.565 5 0.717 0.00409
8 khellin −0.418 5 −0.708 0.00467
9 PNU-0251126 −0.358 6 −0.656 0.00467
10 metampicillin 0.389 5 0.704 0.00537
11 CP-645525-01 −0.558 3 −0.861 0.00553
12 minoxidil −0.446 5 −0.694 0.00597
13 spiradoline −0.478 4 −0.756 0.00718
14 PHA-00816795 −0.719 2 −0.942 0.00722
15 acenocoumarol 0.509 5 0.687 0.00741
16 cefotaxime 0.561 5 0.682 0.00845
17 metrizamide 0.487 4 0.731 0.01044
18 Y-27632 −0.674 2 −0.922 0.01223
19 bacampicillin −0.354 4 −0.718 0.01271
20 levocabastine 0.274 4 0.718 0.01297
  1. Mean:the arithmetic mean of the connectivity scores for corresponding instances, N:The number of instances, Enrichment: The degree of enrichment of the given instance in all instances, P-value:an estimate of the likelihood that the enrichment of a set of predicted potential drugs of all CMap drugs would be observed by chance