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Table 3 Chemical compounds identified by Connectivity map and list the top 20 ranked by P-value

From: Identification of target genes in cardiomyopathy with fibrosis and cardiac remodeling

rank

cmap name

Mean

n

enrichment

P-value

1

tridihexethyl

−0.64

4

− 0.883

0.00044

2

Prestwick-682

−0.509

4

−0.848

0.00097

3

fluoxetine

−0.494

4

−0.806

0.00271

4

pirlindole

−0.668

3

−0.884

0.00312

5

methyldopa

0.382

5

0.732

0.00318

6

ciclacillin

0.494

4

0.789

0.00391

7

sulfadiazine

0.565

5

0.717

0.00409

8

khellin

−0.418

5

−0.708

0.00467

9

PNU-0251126

−0.358

6

−0.656

0.00467

10

metampicillin

0.389

5

0.704

0.00537

11

CP-645525-01

−0.558

3

−0.861

0.00553

12

minoxidil

−0.446

5

−0.694

0.00597

13

spiradoline

−0.478

4

−0.756

0.00718

14

PHA-00816795

−0.719

2

−0.942

0.00722

15

acenocoumarol

0.509

5

0.687

0.00741

16

cefotaxime

0.561

5

0.682

0.00845

17

metrizamide

0.487

4

0.731

0.01044

18

Y-27632

−0.674

2

−0.922

0.01223

19

bacampicillin

−0.354

4

−0.718

0.01271

20

levocabastine

0.274

4

0.718

0.01297

  1. Mean:the arithmetic mean of the connectivity scores for corresponding instances, N:The number of instances, Enrichment: The degree of enrichment of the given instance in all instances, P-value:an estimate of the likelihood that the enrichment of a set of predicted potential drugs of all CMap drugs would be observed by chance