Table 1 Baseline patient characteristics
Variables | Total | HBeAg-negative | HBeAg-positive | P Value |
|---|---|---|---|---|
Mean ± SD or N (%) | (n = 271) | (n = 170) | (n = 101) | |
Age | 47.39 ± 11.35 | 51.57 ± 10.45 | 40.37 ± 10.44 | < 0.0001T |
Gender | 0.6454C | |||
Man | 187 (69.0) | 119 (70.0) | 68 (67.33) | |
Woman | 84 (31.0) | 51 (30.0) | 33 (32.67) | |
Genotype | 0.0003C | |||
B | 166 (62.88) | 118 (71.08) | 48 (48.98) | |
C | 98 (37.12) | 48 (28.92) | 50 (51.02) | |
HBsAg: log10 IU/mL | 3.34 ± 0.84 | 3.04 ± 0.89 | 3.85 ± 0.66 | < 0.0001T |
HBV DNA: log10 IU/mL | 6.89 ± 2.16 | 5.91 ± 1.84 | 8.56 ± 0.93 | < 0.0001T |
Cirrhosis | 0.0028C | |||
No | 182 (67.16) | 103 (60.59) | 79 (78.22) | |
Yes | 89 (32.84) | 67 (39.41) | 22 (21.78) | |
Fatty liver | 0.2510C | |||
No | 133 (49.08) | 88 (51.76) | 45 (44.55) | |
Yes | 138 (50.92) | 82 (48.42) | 56 (55.45) | |
Albumin: g/dL | 4.07 ± 0.51 | 4.04 ± 0.54 | 4.10 ± 0.48 | 0.5446T |
ALT: IU/L | 281.5 ± 411.2 | 210.8 ± 333.2 | 400.5 ± 472.3 | 0.0002T |
Total bilirubin: mg/dL | 1.40 ± 1.34 | 1.32 ± 0.95 | 1.54 ± 1.54 | 0.7096T |
Platelet: × 103/μL | 161.0 ± 60.73 | 149.4 ± 65.8 | 180.8 ± 58.1 | 0.0004T |
PT: seconds prolonged | 1.71 ± 2.00 | 1.69 ± 1.73 | 1.86 ± 1.91 | 0.3551T |
Cr: mg/dL | 0.88 ± 0.49 | 0.90 ± 0.61 | 0.86 ± 0.40 | 0.2857T |
AFP: ng/mL | 25.31 ± 75.62 | 21.24 ± 44.57 | 32.17 ± 89.88 | 0.4094T |
Numbers of liver biopsy | 164 | 105 | 59 | |
METAVIR Activity grade | 0.5302C | |||
0,1 | 97 (59.15) | 64 (60.95) | 33 (55.93) | |
2,3 | 67 (40.85) | 41 (39.05) | 26 (44.07) | |
METAVIR Fibrosis stage | 0.0949C | |||
0–2 | 91 (57.59) | 52 (52.53) | 39 (66.10) | |
3,4 | 67 (42.41) | 47 (47.47) | 20 (33.90) | |