Skip to main content

Table 4 Factors associated with HBeAg loss in HBeAg-positive patients

From: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection

Variables

Univariate analysis

Multivariate analysis

Hazard Ratio (95% CI)

P Value

Hazard Ratio (95% CI)

P Value

Age: ≥ 40 vs < 40 years old

0.693 (0.408–1.179)

0.1761

 

Sex: Man vs Woman

1.103 (0.609–1.996)

0.7466

Genotype: C vs B

1.118 (0.661–1.892)

0.6774

Cirrhosis: Yes vs No

1.150 (0.617–2.144)

0.6591

HBsAg: 2900–12,000 vs

<  2900 or > 12,000 IU/mL

2.696 (1.555–4.673)

0.0004

2.108 (1.133–3.924)

0.0186

HBV DNA: ≥ 8.3 vs

<  8.3 log10 IU/mL

0.938 (0.534–1.646)

0.8223

 

ALT: ≥ 5 × vs < 5 × ULN

2.452 (1.433–4.195)

0.0011

2.055 (1.145–3.690)

0.0158

Total bilirubin: ≥ 1.2 vs

<  1.2 mg/dL

1.622 (0.959–2.744)

0.0713

 

PT: seconds prolonged

1.130 (0.995–1.282)

0.0592

1.140 (0.981–1.325)

0.0865

Platelet: ≥ 150 vs < 150 × 103/μL

1.551 (0.887–2.710)

0.1234

 

AFP: ≥ 20 vs < 20 ng/mL

3.178 (1.732–5.829)

0.0002

2.583 (1.258–5.303)

0.0097

CLEC18: pg/mL

1.000 (0.999–1.000)

0.2708

 

CLEC18: 320–2000 vs

<  320 or > 2000 pg/mL

2.842 (1.637–4.933)

0.0002

2.077 (1.066–4.046)

0.0318