Skip to main content

Table 4 Factors associated with HBeAg loss in HBeAg-positive patients

From: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection

Variables Univariate analysis Multivariate analysis
Hazard Ratio (95% CI) P Value Hazard Ratio (95% CI) P Value
Age: ≥ 40 vs < 40 years old 0.693 (0.408–1.179) 0.1761  
Sex: Man vs Woman 1.103 (0.609–1.996) 0.7466
Genotype: C vs B 1.118 (0.661–1.892) 0.6774
Cirrhosis: Yes vs No 1.150 (0.617–2.144) 0.6591
HBsAg: 2900–12,000 vs
<  2900 or > 12,000 IU/mL
2.696 (1.555–4.673) 0.0004 2.108 (1.133–3.924) 0.0186
HBV DNA: ≥ 8.3 vs
<  8.3 log10 IU/mL
0.938 (0.534–1.646) 0.8223  
ALT: ≥ 5 × vs < 5 × ULN 2.452 (1.433–4.195) 0.0011 2.055 (1.145–3.690) 0.0158
Total bilirubin: ≥ 1.2 vs
<  1.2 mg/dL
1.622 (0.959–2.744) 0.0713  
PT: seconds prolonged 1.130 (0.995–1.282) 0.0592 1.140 (0.981–1.325) 0.0865
Platelet: ≥ 150 vs < 150 × 103/μL 1.551 (0.887–2.710) 0.1234  
AFP: ≥ 20 vs < 20 ng/mL 3.178 (1.732–5.829) 0.0002 2.583 (1.258–5.303) 0.0097
CLEC18: pg/mL 1.000 (0.999–1.000) 0.2708  
CLEC18: 320–2000 vs
<  320 or > 2000 pg/mL
2.842 (1.637–4.933) 0.0002 2.077 (1.066–4.046) 0.0318