Table 5 Factors associated with HBeAg seroconversion in the HBeAg-positive patients
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |
Age: ≥ 40 vs < 40 years old | 0.700 (0.363–1.351) | 0.2878 | ||
Sex: Man vs Woman | 0.741 (0.370–1.485) | 0.3984 | ||
Genotype: C vs B | 1.480 (0.756–2.898) | 0.2525 | ||
Cirrhosis: Yes vs No | 1.133 (0.532–2.411) | 0.7464 | ||
HBsAg: 2900–12,000 vs < 2900 or > 12,000 IU/mL | 1.754 (0.897–3.340) | 0.1008 | ||
HBV DNA: ≥ 8.3 vs < 8.3 log10 IU /mL | 0.907 (0.453–1.815) | 0.7832 | ||
ALT: ≥ 5 × vs < 5 × ULN | 3.115 (1.551–6.254) | 0.0014 | 2.562 (1.241–5.288) | 0.0110 |
Total bilirubin: ≥ 1.2 vs < 1.2 mg/dL | 1.392 (0.723–2.682) | 0.3228 | ||
PT: seconds prolonged | 1.114 (0.955–1.298) | 0.1688 | ||
Platelet: ≥ 150 vs < 150 × 103/μL | 1.149 (0.565–2.336) | 0.7021 | ||
AFP: ≥ 20 vs < 20 ng/mL | 2.388 (1.166–4.888) | 0.0173 | 1.950 (0.927–4.103) | 0.0783 |
CLEC18: pg/mL | 1.000 (0.999–1.000) | 0.3755 | ||
CLEC18: 320–2000 vs < 320 or > 2000 pg/mL | 2.609 (1.342–5.072) | 0.0047 | 2.041 (1.018–4.092) | 0.0445 |