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Table 5 Factors associated with HBeAg seroconversion in the HBeAg-positive patients

From: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection

Variables Univariate analysis Multivariate analysis
Hazard Ratio (95% CI) P Value Hazard Ratio (95% CI) P Value
Age: ≥ 40 vs < 40 years old 0.700 (0.363–1.351) 0.2878
Sex: Man vs Woman 0.741 (0.370–1.485) 0.3984
Genotype: C vs B 1.480 (0.756–2.898) 0.2525
Cirrhosis: Yes vs No 1.133 (0.532–2.411) 0.7464
HBsAg: 2900–12,000 vs
<  2900 or > 12,000 IU/mL
1.754 (0.897–3.340) 0.1008
HBV DNA: ≥ 8.3 vs < 8.3 log10 IU /mL 0.907 (0.453–1.815) 0.7832
ALT: ≥ 5 × vs < 5 × ULN 3.115 (1.551–6.254) 0.0014 2.562 (1.241–5.288) 0.0110
Total bilirubin: ≥ 1.2 vs < 1.2 mg/dL 1.392 (0.723–2.682) 0.3228
PT: seconds prolonged 1.114 (0.955–1.298) 0.1688
Platelet: ≥ 150 vs < 150 × 103/μL 1.149 (0.565–2.336) 0.7021
AFP: ≥ 20 vs < 20 ng/mL 2.388 (1.166–4.888) 0.0173 1.950 (0.927–4.103) 0.0783
CLEC18: pg/mL 1.000 (0.999–1.000) 0.3755
CLEC18: 320–2000 vs
<  320 or > 2000 pg/mL
2.609 (1.342–5.072) 0.0047 2.041 (1.018–4.092) 0.0445