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Table 6 Factors associated with virological response in the HBeAg-positive patients

From: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection

Variables Univariate analysis Multivariate analysis
Hazard Ratio (95% CI) P Value Hazard Ratio (95% CI) P Value
Age: ≥ 40 vs < 40 years old 0.813 (0.544–1.215) 0.3125
Sex: Man vs Woman 0.755 (0.488–1.166) 0.2045
Genotype: C vs B 1.063 (0.707–1.598) 0.7691
Cirrhosis: Yes vs No 1.257 (0.778–2.031) 0.3502
HBsAg: 2900–12,000 vs
<  2900 or > 12,000 IU/mL
1.698 (1.065–2.706) 0.0260 1.449 (0.890–2.359) 0.1359
HBV DNA: ≥ 8.3 vs < 8.3 log10 IU/mL 0.583 (0.378–0.899) 0.0147 0.395 (0.247–0.631) 0.0001
ALT: ≥ 5 × vs < 5 × ULN 1.909 (1.240–2.939) 0.0033 2.191 (1.373–3.496) 0.0010
Total bilirubin: ≥ 1.2 vs < 1.2 mg/dL 1.301 (0.861–1.967) 0.2115
PT: seconds prolonged 1.015 (0.914–1.128) 0.7751
Platelet: ≥ 150 vs < 150 × 103/μL 1.297 (0.831–2.025) 0.2525
AFP: ≥ 20 vs < 20 ng/mL 1.230 (0.742–2.038) 0.4227
CLEC18: pg/mL 1.000 (1.000–1.000) 0.9850
CLEC18: 320–2000 vs
<  320 or > 2000 pg/mL
1.979 (1.238–3.163) 0.0044 1.850 (1.109–3.085) 0.0184