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Table 6 Factors associated with virological response in the HBeAg-positive patients

From: The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection

Variables

Univariate analysis

Multivariate analysis

Hazard Ratio (95% CI)

P Value

Hazard Ratio (95% CI)

P Value

Age: ≥ 40 vs < 40 years old

0.813 (0.544–1.215)

0.3125

Sex: Man vs Woman

0.755 (0.488–1.166)

0.2045

Genotype: C vs B

1.063 (0.707–1.598)

0.7691

Cirrhosis: Yes vs No

1.257 (0.778–2.031)

0.3502

HBsAg: 2900–12,000 vs

<  2900 or > 12,000 IU/mL

1.698 (1.065–2.706)

0.0260

1.449 (0.890–2.359)

0.1359

HBV DNA: ≥ 8.3 vs < 8.3 log10 IU/mL

0.583 (0.378–0.899)

0.0147

0.395 (0.247–0.631)

0.0001

ALT: ≥ 5 × vs < 5 × ULN

1.909 (1.240–2.939)

0.0033

2.191 (1.373–3.496)

0.0010

Total bilirubin: ≥ 1.2 vs < 1.2 mg/dL

1.301 (0.861–1.967)

0.2115

PT: seconds prolonged

1.015 (0.914–1.128)

0.7751

Platelet: ≥ 150 vs < 150 × 103/μL

1.297 (0.831–2.025)

0.2525

AFP: ≥ 20 vs < 20 ng/mL

1.230 (0.742–2.038)

0.4227

CLEC18: pg/mL

1.000 (1.000–1.000)

0.9850

CLEC18: 320–2000 vs

<  320 or > 2000 pg/mL

1.979 (1.238–3.163)

0.0044

1.850 (1.109–3.085)

0.0184